王晓珂  副教授

   王晓珂，女，1983.05出生，华中科技大学1000拍拍拍兔费芒果585医学博士，美国马里兰大学医学院博士后。现任职于1000拍拍拍兔费芒果585职业医学与环境毒理学系，副教授，硕士生导师，主要从事孕期颗粒物和重金属暴露对肥胖、糖尿病和非酒精性脂肪肝等慢性病发生的影响及相关分子机制研究。曾先后主持了国家自然科学基金青年基金、江苏省自然科学基金青年基金和江苏省高校自然科学基金面上项目等多项省部级课题。近年来以第一作者和通讯作者身份在《Particle and Fibre Toxicology》、《Toxicological Sciences》、《Environmental Pollution》、《ACS Nano》和《Free Radical Biology and Medicine》等期刊发表SCI论文10余篇，其中中科院二区及以上论文9篇。目前担任江苏省毒理学会基础毒理青年委员会委员，江苏省环境诱变剂协会理事，江苏省环境卫生学专业委员会委员，南通市医学会内分泌学会委员。

招生方向： 环境毒理

代表论文：

1. Xiaoke Wang; Zixuan Zhao; Xin Wang; Wenxuan Hu; Chao Luo; Xiuyu Chu; Muzhou Qian; Rui Wang; Shali Yu; Qiyun Wu; Juan Tang; Xinyuan Zhao ; Effects of polystyrene nanoplastic gestational exposure on mice, Chemosphere, 2023, 334

2. Xiaoke Wang; Peiyao Zhou; Ziyang Zhang; Qiuru Huang; Xia Chen; Li Ji; Xinmeng Cheng; Yi Shi; Shali Yu; Juan Tang; Chi Sun; Xinyuan Zhao; Jun Yu ; A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis, Free Radical Biology and Medicine, 2023, 208: 418-429

3. Juan Tang; Wenxia Bu; Wenxuan Hu; Zixuan Zhao; Lei Liu; Chao Luo; Rui Wang; Susu Fan; Shali Yu; Qiyun Wu^*; Xiaoke Wang^*; Xinyuan Zhao^*; Ferroptosis Is Involved in Sex-Specific Small Intestinal Toxicity in the Offspring of Adult Mice Exposed to Polystyrene Nanoplastics during Pregnancy, ACS Nano, 2023, 17(3): 2440-2449

4. Xu, Shenya; Yang, Zeyun; Zhi, Ye; Yu, Shali; Zhang, Tao; Jiang, Junkang; Tang, Jun; He, Hongsen; Lu, Ming; Wang, Xiaoke*; Wu, Qiyun*; Zhao, Xinyuan*. The effects of antimony on Alzheimer's disease-like pathological changes in mice brain, Science Of The Total Envirovment, 2021, 760, DOI: 10.1016/j.scitotenv.2020.143235

5. Xiaoke Wang; Yuxue Yang; Piaoyu Zhu; Yifan Wu; Yang Jin; Shali Yu; Haiyan Wei; Muzhou Qian; Weiming Cao; Shenya Xu; Yingqi Liu; Gang Chen; Xinyuan Zhao ; Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet, Environmental Pollution, 2019, 255

6. Xiaoke Wang; Piaoyu Zhu; Shenya Xu; Yuting Liu; Yang Jin; Shali Yu; Haiyan Wei; Jinlong Li; Qinglin Zhang; Takahiro Hasegawa; Chenjuan Yao; Hiroshi Yoshimura; Qiyun Wu; Xinyuan Zhao ; Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen speciesmediated inhibition of the protein kinase B/mammalian target of rapamycin pathway, International Journal of Biochemistry & Cell Biology, 2019, 114

7. Chen Minjie, Wang Xiaoke(co-first), Hu Ziying, Zhou Huifen, Xu Yanni, Qiu Lianglin, Qin Xiaobo, Zhang Yuhao, and Ying Zhekang, Programming of mouse obesity by maternal exposure to concentrated ambient fine particles. Part Fibre Toxicol, 2017, 14(1): 20.

8.  Zhao Xingyuan, Xing Fengjun, Cong Yewen., Zhuang Yin, Han Muxi, Wu Zhiqiang, Yu Shali, Wei Haiyan, Wang Xiaoke*, and Chen Gang. Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells. Int J Biochem Cell Biol, 2017. 93: 32-40.

9.Yu Shali., Xu Lingfei, Wu Junxia, Yao Chenjuan, Hu Qiaoyun, Zhang Chunxue, Zhao Xinyuan, Wei Haiyan, Wang Xiaoke*, and Chen Gang. Increased PIT1 and PIT2 Expression in Streptozotocin (STZ)-induced Diabetic Mice Contributes to Uptake of iAs(V). Biomed Environ Sci, 2017. 30(11): 792-801.

10.  Zhao Xinyuan, Jin Yang, Yang Lijia, Hou Zhengxing, Liu Yingqi, Sun Tianyu, Pei Jiaxin, Li Jinlong, Yao Chenjuan, Wang Xiaoke*, Chen Gang*. Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells. Toxicol Lett 2018, 296:73-81.

11.  Xiaoke Wang, Aiguo Ge, Mengjie Cheng, Min Zhao, Xiaoqi Zhou, Liegang Liu, Nianhong Yang*. Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet. Experimental Diabetes, 2012, Research, doi:10.1155/2012/847246

12  Xiaoke Wang, Mengjie Cheng, Min Zhao, Aiguo Ge, Fangfang Guo, Min Zhang, Yanhong Yang, Liegang Liu, Nianhong Yang*. Differential effects of high-fat-diet rich in lard  oil or soybean oil on osteopontin expression and inflammation of adipose tissue in diet-induced obese rats. Eur J Nutr, 2013, 52(3):1181-118

13.Hu Ziying, Chen Miniie, Zhou Huifen, Tharakan Anui, Wang Xiaoke, Qiu Lianglin, Liang Shuai, Qin Xiaobo, Zhang Yuhao, Wang Wanjun, Xu Yanni, and Ying Zhekang. Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5. Toxicology, 2017. 390: 100-108.

14. 刘天娥，赵健亚，陈刚，王晓珂*。白藜芦醇和能量限制对大鼠肝脂肪变性影响，中国公共卫生，2014，30（7）: 915-917

15. 王晓珂，赵健亚，刘天娥，蒋建中，张璇，王春，陈刚*。白藜芦醇对大鼠非酒精性脂肪肝的作用及机制研究。毒理学杂志，2013，27（6）：450-453

16. 赵健亚， 刘天娥， 肖静， 王晓珂*。NOD受体在大鼠骨骼肌胰岛素抵抗中作用。中国公共卫生，2013，29（12）:1785-1787

17. 王晓珂，刘天娥，蒋建中，张璇，陈刚，赵健亚*。白藜芦醇对肥胖易感和肥胖抵抗大鼠体重的影响。营养学报，2013，35（6）： 577-581

科研项目：

1. 南通市售海产品中微塑料的污染特征分析及纳米微塑料暴露对非酒精性脂肪肝发生的影响, 江苏省南通市科技局,面上项目, 2022.07-2024.06, 10万元, 在研, 主持

2. 出生前PM2.5 暴露对非酒精性脂肪肝发生的影响及机制研究，南通市科技局项目2019.07 - 2021.06, 3.2万元，已结题，主持